Arjun Athreya, Ravishankar Iyer, Drew Neavin, Liewei Wang, Richard Weinshilboum, Rima Kaddiurah-Daouk, John Rush, Mark Frye, William Bobo (2018). Augmentation of Physician Assessments with Multi-Omics Enhances Predictability of Drug Response: A Case Study of Major Depressive Disorder. IEEE Computational Intelligence Magazine, 13(3), 20-31."What we're doing is then taking these organoids and using them as a barometer of what the outside influence that is the drugs, we actually use to study them do," Dr. Weinshilboum said. In order to create a mini brain, the stem cells need to be constantly moving. There wasn't a machine at Mayo Clinic that could complete this task.2 Ratings. Learn more. These providers are on the medical staff of Mayo. Dr. Richard Weinshilboum, MD is an internal medicine specialist in Rochester, MN and has over 50 years of experience in the medical field. He graduated from UNIVERSITY OF KANSAS / SCHOOL OF MEDICINE in 1972. When Richard Nixon resigned in 1974, he was widely disliked as a consequence of the Watergate scandal. Although some consider him to have a few redeeming qualities, Watergate is conceded to be evidence of his being unfit to lead, hence his ...Richard Weinshilboum. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA. Search for more papers by this authorRichard Weinshilboum. 2015, Clinical pharmacology and therapeutics. The scaling up of data in clinical pharmacology and the merger of systems biology and pharmacology has led to the emergence of a new discipline of Quantitative and Systems Pharmacology (QSP). This new research direction might significantly advance the discovery, development and ...Acetaminophen is the leading cause of acute hepatic failure in many developed nations. Acetaminophen hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinonimine (NAPQI).We performed a "discovery" genome-wide association study using a cell line-based model system to study the possible contribution of genomics to NAPQI-induced cytotoxicity.Original Research: Full open access research for "Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate " by V M Karpyak, J M Biernacka, J R Geske, G D Jenkins, J M Cunningham, J Rüegg, O Kononenko, A A Leontovich, O A Abulseoud, D K Hall-Flavin, L L Loukianova, T D Schneekloth, M K Skime ...Reactive PGx testing was cost-effective for 45–54 years old (ICER of $95,480) and was not cost-effective for age ≥55 years old. Compared with usual care, preemptive tests had higher ICER ($91,451/QALY) among male patients than female patients ($80,921/QALY) and both groups were cost-effective. Reactive tests were not cost-effective for male ..."To our knowledge, it's the first time anyone has applied this approach to COVID-19," says Richard Weinshilboum, M.D., co-author of the study and a pharmacologist in the Center for Individualized ...Richard Weinshilboum, M.D., Interim Director, Center for Individualized Medicine, Division Chair -Clinical Pharmacology, Professor of Medicine and Pharmacology. Mat Wiepert, M.S., Section Head, Information Technology, Instructor in Biomedical Informatics University of Illinois MembersIntroduction. Clopidogrel remains the most widely prescribed anti-platelet drug in the US and Canada. 1,2 In an analysis of 64,600 patients who underwent PCI at 47 Michigan Hospitals, the proportion of patients receiving clopidogrel, prasugrel and ticagrelor was 72%, 20% and 8%, respectively. Clopidogrel is a prodrug requiring the cytochrome P450 (CYP) enzymes for …Introduction. Primary prevention of breast cancer remains a major goal for reducing the burden associated with this disease. Two large breast cancer prevention trials of selective estrogen receptor modulators (SERMs) including the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 placebo-controlled trial of tamoxifen [] and double-blind NSABP P-2 trial comparing raloxifene to ...Finally, we generated cisplatin dose responses in 3D cultures of breast cancer cells derived from 2 PDX models. Results: The microfluidic platform allows the simultaneous culture of 96 perfused micro tissues, using limited amounts of material, enabling drug screening of patient-derived material. 3D cell culture viability is improved by constant ...Richard Weinshilboum 1 , Liewei Wang Affiliation 1 Mayo Medical School-Mayo Graduate School, Mayo Clinic College of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, Minnesota 55905, USA. [email protected] Biographical summary. Ann M. Moyer, M.D., Ph.D., is board certified in molecular genetic pathology, anatomic pathology, and clinical pathology. She is an Associate Professor of Laboratory Medicine and Pathology and an Assistant Professor of Pharmacology. Dr. Moyer earned her bachelor's degrees double majoring in Biology and Chemistry at the ...June 3, 2022. New Computational Benchmark Helps the Design and Selection of Drug Discovery Al Models. Drug repurposing to expand treatment options for patients leaps forward with an advance in machine learning from Mayo Clinic researchers and collaborators. Led by the lab of Nansu Zong, Ph.D., the team has created the gold-standard ...Chapter 6: Estrogen Metabolism by Conjugation Rebecca Raftogianis, Cyrus Creveling, Richard Weinshilboum, Judith Weisz trone and 17-estradiol, are both ligands for the ERs, although The involvement of estrogens in carcinogenic processes those receptors have higher affinity for 17-estradiol than for within estrogen-responsive tissues has been recognized for a estrone and it is 17 ...As a fashion-forward woman, it’s important to stay up-to-date on the latest trends in apparel. Anthony Richards offers a wide selection of stylish and affordable clothing that will keep you looking chic and fashionable."What we're doing is then taking these organoids and using them as a barometer of what the outside influence that is the drugs, we actually use to study them do," Dr. Weinshilboum said. In order to create a mini brain, the stem cells need to be constantly moving. There wasn't a machine at Mayo Clinic that could complete this task.Kjeld Schmiegelow, 1, 2 Ibrahim Al-Modhwahi, 2 Mette Klarskov Andersen, 3 Mikael Behrendtz, 4 Erik Forestier, 5 Henrik Hasle, 6 Mats Heyman, 7 Jon Kristinsson, 8 Jacob Nersting, 2 Randi Nygaard, 9 Anne Louise Svendsen, 10 Kim Vettenranta, 11 and Richard Weinshilboum 12, for the Nordic Society for Paediatric Haematology and OncologyDrew Neavin & Richard Weinshilboum. Mayo Graduate School, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Drew Neavin. Department of Psychiatry and Behavioral Medicine, Duke Institute for Brain Sciences, 3552, Blue Zone, Duke South, Durham, NC, 27710, USA. Rima Kaddurah-DaoukDr. Weinshilboum says this study is a steppingstone in developing the foundations necessary to use DNA sequencing in helping to guide clinical care. Key components in the successful implementation of this study included pharmacogenomics education programs for medical staff, information technology support to build and implement the data ...Dr. Richard M. Weinshilboum will initiate the 2012 NICHD Director's Lecture Series with a lecture on Pharmacogenomics: Beyond Biomarkers.Dr. Weinshilboum is the Mary Lou and John H. Dasburg Professor for Cancer Genomics Research, the chair of the Division of Clinical Pharmacology, and a professor of Molecular Pharmacology and Experimental Therapeutics and Medicine at the Mayo Clinic in ...AU - Weinshilboum, Richard. AU - Biernacka, Joanna M. N1 - Funding Information: The PGRN-AMPS study was supported by U19 GM61388 and R01 GM28157 (to Drs Liewei Wang and Richard Weinshilboum). Dr. Bobo's research has been supported by the National Institute of Mental Health, the Mayo Foundation for Medical Education and Research, and the Brain ...Pharmacogenomics is the use of genomic and other “omic” information to individualize drug selection and drug use in order to avoid adverse drug reactions and to maximize drug efficacy. The science underlying pharmacogenomics has evolved rapidly over the 50 years since it was first suggested that genetics might influence drug response ...Richard Weinshilboum, M.D. From the Departments of Molecular Phar-macology and Experimental Therapeutics and Medicine, Mayo Medical School, Mayo Clinic, and Mayo Foundation, Rochester,author = "Goetz, {Matthew P.} and Kalari, {Krishna R.} and Suman, {Vera J.} and Moyer, {Ann M.} and Jia Yu and Visscher, {Daniel W.} and Dockter, {Travis J.} and Vedell, {Peter T.} and Sinnwell, {Jason P.} and Xiaojia Tang and Thompson, {Kevin J.} and McLaughlin, {Sarah A.} and Alvaro Moreno-Aspitia and Copland, {John A.} and Northfelt, {Donald W.} and Gray, {Richard J.} and Katie Hunt and Amy ...Original Research: Full open access research for "Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate " by V M Karpyak, J M Biernacka, J R Geske, G D Jenkins, J M Cunningham, J Rüegg, O Kononenko, A A Leontovich, O A Abulseoud, D K Hall-Flavin, L L Loukianova, T D Schneekloth, M K Skime ...Yuan Ji, 1, † Joanna Biernacka, 2, 3, † Karen Snyder, 2 Maureen Drews, 2 Linda L. Pelleymounter, 1 Colin Colby, 3 Liewei Wang, 1 David A. Mrazek, 2 and Richard M. Weinshilboum 1 Yuan Ji 1 Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USARichard Weinshilboum, M.D., interim director for the Center for Individualized Medicine, is helping to lead Mayo’s efforts to integrate pharmacogenomics into clinical practice. He says Dr. Cutrer’s study is just one example of how the center is working to improve treatments and reduce harmful side effects.Dr. Richard Weinshilboum "When you look at the clinical application of genomics, everyone thinks of cancer — and this is appropriate, because cancer is a genomic disease," Dr. Weinshilboum says. "However, the aspect of clinical genomics that will affect everyone everywhere is pharmacogenomics," or how an individual's genetic makeup ...Richard Weinshilboum from the Mayo Clinic in Rochester, Minnesota, USA, and colleagues previously showed that genetic variations in or near two genes—ZNF423 and CTSO—affected how well the ...Richard Weinshilboum [email protected] Specialty section: This article was submitted to Pharmacogenetics and Pharmacogenomics, a section of the journal Frontiers in PharmacologyThese observations increase our understanding of mechanisms of non-coding genetic variant-chemical environment interactions and advance the fine-mapping of disease risk and pharmacogenomic loci. ### Competing Interest Statement Drs. Richard Weinshilboum and Liewei Wang are co-founders and stockholders in OneOme, LLC.25 មីនា 2021 ... Jia Yu, Bo Qin, Richard Weinshilboum, Matthew P. Goetz & Liewei Wang. Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA. Bo Qin ...Residencies and fellowships; 300+ GME programs in all medical and surgical specialties; Health sciences education; 140+ programs, internships, and rotations in 50 health sciences fieldsRichard WEINSHILBOUM, Da burg Professor of Cancer Genomics Research, Professor of Pharmacology and Medicine | Cited by 44,675 | of Mayo Foundation for Medical Education and Research, FL (MMS ...ORCID record for Zhenkun Lou. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities.Dr. Richard Weinshilboum and Arjun Athreya at ASCPT 2017. Congratulations to Arjun Athreya on his best paper award from BDCAT 2016! Dr. Estrada, the Estrada family, thesis committee and DEPEND members after his final exam. DEPEND members celebrating Homa's Hooding and Commencement ceremony at Prof. Iyer's residence.Richard Weinshilboum Background and purpose: Acamprosate is an anti-craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, only some patients achieve optimal therapeutic ... Richard M Weinshilboum & William V Bobo; Arjun P Athreya. Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Search for more papers by this author, ... L Wang and RM Weinshilboum are co-founders and stockholders in OneOme LLC. WV Bobo's research has been supported by the National …Competing interests: Drs. Weinshilboum and Wang are co-founders of and stockholders in OneOme, LLC, a pharmacogenomics decisions support company. All other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.AU - Weinshilboum, Richard. AU - Wang, Liewei. N1 - Funding Information: Supported, in part, by NIH grants RO1 CA196640 (Liewei Wang) and U19 GM61388 (Liewei Wang and Richard Weinshilboum) as well as support provided by the Mayo Clinic Center for Individualized Medicine Pharmacogenomics Translational Program.Funding support for the Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) was provided by the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH), through the PGRN grant to Principal Investigators R. Weinshilboum and L. Wang (U19 GM61388). Dr. D.Drs L Wang and RM Weinshilboum are co-founders and stockholders in OneOme. Dr. WV Bobo's research has been supported by the National Institute of Mental Health, the Agency for Healthcare Quality and Research, the National Science Foundation, the Myocarditis Foundation, and the Mayo Foundation for Medical Education and Research.Richard Weinshilboum, Division of Clinical Pharmacology, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic ... Ames MM, Jenkins GD, Batzler A, Carlson EE, Flockhart DA, Wolmark N, Nakamura Y, Weinshilboum RM. Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression ...View M. Richard Weinshilboum's profile on LinkedIn, the world's largest professional community. M. has 1 job listed on their profile. See the complete profile on LinkedIn and discover M.'s ...Selective serotonin reuptake inhibitors (SSRIs) are a standard of care for the pharmacotherapy of patients suffering from Major Depressive Disorder (MDD). However, only one-half to two-thirds of MDD patients respond to SSRI therapy. Recently, a "multiple omics" research strategy was applied to identify genetic differences between patients who ...Dr. Richard Weinshilboum, MD is an Internal Medicine Specialist in Rochester, MN and has 51 years experience. They graduated from UNIVERSITY OF KANSAS / SCHOOL OF MEDICINE. They currently practice at Practice. Their office is not accepting new patients. Dr. Weinshilboum is board certified in Internal Medicine.Adkins Pogue, Andrea (2010) Public Services Librarian B.A., University of New Mexico M.L.I., San Jose State UniversityRichard M Weinshilboum, MD. Professor, Rochester, MN, Pharmacology. Email weinshilboum.richard @ mayo. edu. 1968 … 2023. Research activity per year. Overview. Fingerprint. Network. Grants (6) Pharmacogenomics is the use of genomic and other “omic” information to individualize drug selection and drug use in order to avoid adverse drug reactions and to maximize drug efficacy. The science underlying pharmacogenomics has evolved rapidly over the 50 years since it was first suggested that genetics might influence drug response ...Richard Weinshilboum Sulfate conjugation catalyzed by sulfotransferase (SULT) enzymes is an important pathway in the biotransformation of many drugs, other xenobiotics, neurotransmitters, and ...Richard Weinshilboum; Molecular Psychiatry (2021) A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression ...Richard Weinshilboum from the Mayo Clinic in Rochester, Minnesota, USA, and colleagues previously showed that genetic variations in or near two genes—ZNF423 and CTSO—affected how well the ...Education & Training. Massachusetts General Hospital Residency, Internal Medicine, 1971 - 1972. Massachusetts General Hospital Residency, Internal Medicine, 1967 - 1969. University of Kansas School of Medicine Class of 1967.15. PMID: 34101624. PMCID: PMC8279591. DOI: Abstract. Androgen receptor-positive prostate cancer (PCa) and estrogen receptor-positive luminal breast cancer (BCa) are generally less responsive to immunotherapy compared with certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated.Award Description | Eligibility | Criteria and Selection | Nomination Submission | Nomination Deadline | Prior Recipients | Donate to this Award . Award Description. The Julius Axelrod Award in Pharmacology was established in 1991 to honor the eminent American pharmacologist who shaped the fields of neuroscience, drug metabolism, and biochemistry and who served as a mentor for numerous now ...Weinshilboum RM, Wang L. Annu Rev Genomics Hum Genet, 7:223-245, 01 Jan 2006 Cited by: 81 articles | PMID: 16948615. Review. Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective. Lesko LJ, Woodcock J. Nat Rev Drug Discov, 3(9):763-769, 01 Sep 2004 Cited by: 78 ...Kaddurah-Daouk R, Weinshilboum RM. Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology. Clin Pharmacol Ther. 2014; 95 (2):154–167. doi: 10.1038/clpt.2013.217. Epub 2013 Nov 5. [Google Scholar]Send reprint requests to: Dr. Richard Weinshilboum, Dept. of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School-Mayo Clinic-Mayo Foundation, Rochester, MN 55905-0001. E-mail: weinshilboum.richard{at}mayo.edu.Richard Weinshilboum. April 11, 2003. Two things we had in common with Joachim: We shared the same culture, and we had the privilege to share a friendship.Richard Weinshilboum Background and purpose: Acamprosate is an anti-craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, only some patients achieve optimal therapeutic ... Jan 26, 2015 · Richard Weinshilboum, M.D., acting director of the Mayo Clinic Center for Individualized Medicine, describes this new, rapidly advancing frontier in medicine and outlines 10 changes that would ... Joanna M. Biernacka, 1, 2 Brandon J. Coombes, 1 Anthony Batzler, 1 Ada Man-Choi Ho, 2 Jennifer R. Geske, 1 Josef Frank, 3 Colin Hodgkinson, 4 Michelle Skime, 2 Colin Colby, 1 Lea Zillich, 3 Sofia Pozsonyiova, 1 Ming-Fen Ho, 5 Falk Kiefer, 6 Marcella Rietschel, 3 Richard Weinshilboum, 5 Stephanie S. O’Malley, 7 Karl Mann, 6 Ray Anton, 8 David ...The PGRN-AMPS study was supported by U19 GM61388 and R01 GM28157 (to Drs. Liewei Wang and Richard Weinshilboum). Dr. Bobo’s research has been supported by the National Institute of Mental Health, the Mayo Foundation, and the Brain and Behavior Research Foundation (formerly NARSAD).Dr. Weinshilboum is a co-founder of and stockholder in OneOme LLC, a pharmacogenomics decision-support company. Dr. Choi is a scientific advisory board member for Peptron Inc.Richard Weinshilboum Background and purpose: Acamprosate is an anti-craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, only some patients achieve optimal therapeutic ... View M. Richard Weinshilboum’s profile on LinkedIn, the world’s largest professional community. M. has 1 job listed on their profile. See the complete profile on LinkedIn and discover M.’s ... Adkins Pogue, Andrea (2010) Public Services Librarian B.A., University of New Mexico M.L.I., San Jose State UniversityRichard Weinshilboum Estrogens are used as drugs and estrogen exposure is a risk factor for hormone-dependent diseases such as breast cancer. Sulfate conjugation is an important pathway for ...The Mayo Clinic and Illinois Alliance for Technology-Based Healthcare was organized in 2010 to advance research, technology and clinical treatment options in health care. The alliance is a framework for collaboration in individualized medicine. It involves innovative educational programs, integrated research activities and projects, and ...The study is partially funded by the National Institutes of Health, co-authors include Vera Suman, Ph.D.; Tanya Hoskin; Mary Kuffel; Stephanie Safgren; Carol Reynolds, M.D.; Matthew Ames, Ph.D.; and Richard Weinshilboum, M.D., all of Mayo Clinic; Martin Filipits, Ph.D.; Raimund Jakesz and Margaretha Rudas of the Medical University of Vienna ...Richard M. Weinshilboum, MD Rochester, Minn. Xanthine oxidase (EC 1.2.3.2) is a cytoplasmic en- zyme that catalyzes the oxidation of endogenous pu-Background Methotrexate is the preferred initial disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, clinically useful tools for individualized prediction of response to methotrexate treatment in patients with RA are lacking. We aimed to identify clinical predictors of response to methotrexate in patients with rheumatoid arthritis (RA) using machine learning ...LA JOLLA—Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with MDD. Now, Salk Institute researchers have discovered differences in growth patterns of neurons of SSRI …Richard M Weinshilboum 1 , Liewei Wang Affiliation 1 Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Medical School-Mayo Foundation, Rochester, Minnesota 55905, USA. [email protected] Areas. Dr. Weinshilboum's research program is focused on pharmacogenomics, the study of the role of inheritance in variation among patients in drug response phenotypes — phenotypes that can vary from severe life-threatening adverse drug reactions at one end of the spectrum to lack of the desired therapeutic drug effect at the other.author = "Goetz, {Matthew P.} and Kalari, {Krishna R.} and Suman, {Vera J.} and Moyer, {Ann M.} and Jia Yu and Visscher, {Daniel W.} and Dockter, {Travis J.} and Vedell, {Peter T.} and Sinnwell, {Jason P.} and Xiaojia Tang and Thompson, {Kevin J.} and McLaughlin, {Sarah A.} and Alvaro Moreno-Aspitia and Copland, {John A.} and Northfelt, {Donald W.} and Gray, {Richard J.} and Katie Hunt and Amy ...Richard Weinshilboum, MD Keynote Speaker: 'Lola Fashioniya-Aje, MD | FDA 11:00 AM Successes, Challenges and Lessons Learned: Tale of Two Digital Health StudiesA new research paper funded in part by the National Heart, Lung and Blood Institute (NHLBI) shows a clear advantage of genetic testing in helping health care prAdkins Pogue, Andrea (2010) Public Services Librarian B.A., University of New Mexico M.L.I., San Jose State UniversityRichard Weinshilboum, M.D., Mayo Clinic . 11:40 am EDT Prenatal Screening Diagnosis & Therapy . Ignatia Van den Veyver, M.D., Baylor College of Medicine . 12:30 pm EDT Lunch Break (30 min) Afternoon Moderator: David Valle, Johns Hopkins University ."As Dr. Richard Weinshilboum, one of my mentors, says: 'It's about the right drug, at the right dose, for the right patient.' That's what we need to focus on." Learn more. Watch Dr. Matthew Goetz discuss systemic therapies for breast cancer in this "Mayo Clinic Q&A" podcast video:
The man who led the mapping of the genome for the NIH has no doubt about Dr. Weinshilboum's leadership in the PGRN and in the science. Francis Collins, M.D., now heads the National Institutes of Health. "Dick is one of the foremost pioneers in the field of pharmacogenomic research," says Francis Collins, M.D., Ph.D., now director of the NIH.. Alex raich
ROCHESTER, Minn. — Brian G.M. Durie, M.D., E. Rolland Dickson, M.D., K. Krishnan Unni, M.D., and Richard Weinshilboum, M.D., have been named recipients of the 2014 ...Conclusion. We found mixed evidence on the cost-effectiveness of PGx in CVD care. Supportive evidence exists for clopidogrel-CYP2C19 and warfarin-CYP2C9/VKORC1, but evidence is limited in other drug-gene combinations.Gaps persist, including unclear explanation of perspective and cost inputs, underreporting of study design elements critical to economic evaluations, and limited examination ...Richard Weinshilboum Sulfate conjugation catalyzed by phenol sulfotransferase (PST) is the major metabolic pathway for methyldopa. Methyldopa is also O-methylated in a reaction catalyzed by ...Richard Weinshilboum Background and purpose: Acamprosate is an anti-craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, only some patients achieve optimal therapeutic ...Dr. Weinshilboum says this study is a steppingstone in developing the foundations necessary to use DNA sequencing in helping to guide clinical care. Key components in the successful implementation of this study included pharmacogenomics education programs for medical staff, information technology support to build and implement the data ...The application of patient-derived xenografts (PDX) in drug screening and testing is a costly and time-consuming endeavor. While cell lines permit extensive mechanistic studies, many human breast cancer cell lines lack patient characteristics and clinical treatment information. Establishing cell lin …Dr. Weinshilboum has devoted decades to researching the mechanisms responsible for large individual variation in drug toxicity or efficacy for diseases as diverse as depression, childhood leukemia and breast cancer. His remarks were made at Mayo Medical School during the second annual Mrazek Lecture, titled "SSRI Pharmacogenomics."Education & Training. Massachusetts General Hospital Residency, Internal Medicine, 1971 - 1972. Massachusetts General Hospital Residency, Internal Medicine, 1967 - 1969. University of Kansas School of Medicine Class of 1967.Kaddurah-Daouk R, Weinshilboum RM. Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology. Clin Pharmacol Ther. 2014; 95 (2):154-167. doi: 10.1038/clpt.2013.217. Epub 2013 Nov 5. [Google Scholar]When Richard Weinshilboum entered the KU School of Medicine anatomy lab more than 50 years ago, he expected to advance his education. He did not expect to meet his lifelong love and future wife, Lily. At the time, Richard was a medical student, and Lily was the graduate teaching assistant for the class.Guest faculty have included Jeanne Lawrence, Stylianos Antonarakis, Goncalo Abecasis, Phil Reilly, Eddy Rubin, Richard Weinshilboum, Jennifer Puck, Rudy ...Sulfate conjugation is an important pathway in the metabolism of many drugs, other xenobiotic compounds, hormones, and neurotransmitters. During the past two decades, the applicant's laboratory has systematically explored the pharmacogenetics of enzymes that catalyze sulfation in humans. As a result of application of the techniques of molecular ....
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